People

People

Principal Investigator

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Keying Zhu

Year
2027-
2026-2027
2024-2026
2023-2024
2017-2023
Position
Principal Investigator
Assistant Professor
Postdoc
Postdoc
PhD
Institute
Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences
Karolinska Institutet
University of California, San Francisco
Karolinska Institutet
Karolinska Institutet
Upon completing my PhD defense (2023.05) and an interim postdoctoral period at Karolinska Institutet, I conducted my postdoctoral training at the University of California, San Francisco (2024–2026). My research primarily focuses on the cellular and molecular mechanisms underlying white matter pathology, with a particular emphasis on the role of microglia in regulating myelin health, damage, and repair. White matter abnormalities and demyelination are common in aging and neurological diseases such as multiple sclerosis, neuromyelitis optica, and Alzheimer’s disease; however, effective strategies to reinforce myelin health and neuronal resilience remain limited. By combining cutting-edge omics, advanced imaging, state-of-the-art mouse genetic tools, immunophenotyping, and toolboxes for manipulating glial function, I aim to establish a mechanistic and translational framework for understanding and fine-tuning microglia-myelin and microglia-neuron interactions in aging and disease, as well as to provide in-depth insights and therapeutic strategies for restoring CNS resilience and combating neurological disorders. As the main applicant, I received funding support from the Swedish Research Council (Vetenskapsrådet), the Swedish Society for Medical Research (SSMF), the Swedish MS Research Foundation (MS-forskningsfonden), the Swedish Neuro Foundation (Neurofonden), and Erik and Edith Fernström Foundation, totaling around $800K. I have served as an ad hoc reviewer for more than 30 manuscripts for journals including Nature Neuroscience, Advanced Science, eLife, Cell Death & Disease, Translational Neurodegeneration, and Neurobiology of Disease. By invitation, I serve as a Guest Editor for Frontiers in Immunology, Frontiers in Cellular Neuroscience, and Journal of Leukocyte Biology.

Team

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Jianing Lin

PhD candidate, MD, MSc
As a senior PhD candidate at Karolinska Institutet, Jianing has developed expertise in the cellular and molecular mechanisms underlying ALS pathogenesis. He is currently investigating the role of microglial osteopontin in regulating ALS progression using a panel of transgenic mouse models and advanced imaging techniques.

Yiming Xia

PhD candidate, MSc
Started as a mentee of Keying during her master’s thesis at Karolinska Institutet, Yiming investigated the mechanistic roles of transcriptional coregulators in regulating microglial function. She later continued as a PhD student in the Wilhelm lab at Karolinska Institutet, where she investigates microglial modulation of medulloblastoma using an iPSC-derived cell system.
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Jingxian Sun

MD/PhD, MSc
After working with Keying in the Wang lab at Fudan University a decade ago, Jingxian is now an attending physician at the First Affiliated Hospital of Ningbo University. Her research aims to elucidate the mechanisms underlying traditional Chinese medicine and acupuncture, driven by a passion for developing novel candidate compounds inspired by TCM for patients with demyelinating diseases.

Yuanyuan He

MD, MSc
As an attending physician at the Children’s Hospital of Fudan University, Yuanyuan complements her clinical work with a strong commitment to research. She has developed a growing interest in glial cell modulation of the hypothalamic–pituitary–adrenal (HPA) axis and its impact on pubertal abnormalities.
 

Key collaborators

Karolinska Institutet, Stockholm
Fudan University, Shanghai
Capital Medical University, Beijing
Jinan University, Guangzhou
UCSF, San Francisco
Sichuan University, Chengdu
Jiangnan University, Wuxi
Sun Yat-sen University, Guangzhou